Add the unique benefits of hyaluronic acid
to your surgical toolbox.
Hyaluronic acid (HA) is a major biochemical difference between fetal and adult wound environments. Hyalomatrix puts HA’s innate tissue regeneration properties in your skilled hands, helping you bring new hope to patients and their families. It features esterified HYAFF, an exceptionally long-lasting form of HA. HYAFF delivers HA to the wound bed in a prolonged manner, facilitating each stage of the healing process.1-5
Provides the foundation for skin grafting and re-epithelialization.
Facilitates cellular infiltration by using an open scaffold—no cross-linking.6
Helps reduce infection risk.
Rebuilds a well-vascularized neodermis as fast as possible, helping protect your patients from infection.1,3,7,8,9
Promotes quality healing.
Provides an adequate wound bed for healing by successful grafting or secondary intention, which may help reduce patient discomfort and hospital stay.1,7,9
Mechanisms of action
The HYAFF technology behind Hyalomatrix is based on hyaluronic acid rather than collagen, making it unique among skin substitutes.
HA binds 1,000 times its weight in water. This helps facilitate cellular migration and creates water-rich space that helps organize collagen, which is key to reducing scar tissue formation.10, 11
HA facilitates an increase in pro-inflammatory cytokines, activating and recruiting native cells—including endothelial cells and fibroblasts.12,13
Presented as fibers, the HYAFF serves as a scaffold, giving the patient’s native cells a place to live, thrive and rebuild tissue. Without cross-linking, the open scaffold allows for cellular infiltration and capillary growth.6
“Patients are healed or grafted within two weeks.”
Ram Velamuri, MD, MS, MRCS, DNB
Learn how Hyalomatrix created complete granulation in a patient with significant osteomyelitis and no reconstructive options.
In this case series, complex surgical wounds treated with Hyalomatrix were shown to achieve a well-vascularized neodermis and wound closure within an average of 40 days.9
Well-established and well-documented.
The roles of HA, HYAFF and Hyalomatrix are supported by more than 800 peer-reviewed published papers.14
Complete wound healing within 6 weeks using Hyalomatrix to obtain healthy granulation tissue, followed by a split-thickness skin graft.**
Soft tissue defect
Necrotizing fasciitis leading to disarticulation in the left hip with exposed bone
68-year-old diabetic female
Diabetes; disarticulation of the left hip due to extensive necrotizing fasciitis; exposed bone, most notably the acetabular region, anterior superior iliac crest and the os pubis.
“There was no wound. It had completely re-epithelialized.”
Hyalomatrix treatment resulted in decreased collagenisation and increased vascularisation in skin biopsies.
Recommended Wound Types
Hyalomatrix consists of two layers: a non-woven pad of esterified HYAFF and a semi-transparent silicone membrane. It’s recommended for:
- Pressure, venous, diabetic ulcers
- Chronic vascular ulcers
- Tunneled/undermined wounds
- Trauma wounds (abrasions, lacerations skin tears)
- Partial- and full-thickness wounds
- Second-degree burns
- Draining wounds
- Surgical wounds (donor sites,/grafts, post-Mohs surgery, post-laser surgery, podiatric, wound dehiscence)
Individuals with a hypersensitivity to hyaluronan and/or its derivatives, or silicone.